Hydrochloric Acid → HCID 22747878, compound

HRID 47763Notes

Reaction equation

HRID 47763 reaction equation
[OH:1][CH2:2][CH:3]([NH:11]C(=O)C)[CH2:4][C:5]1[CH:10]=[N:9][CH:8]=[CH:7][N:6]=1.[ClH:15]>>[ClH:15].[ClH:15].[NH2:11][CH:3]([CH2:4][C:5]1[CH:10]=[N:9][CH:8]=[CH:7][N:6]=1)[CH2:2][OH:1]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 22747907N-[(1RS)-1-hydroxymethyl-2-(2-pyrazinyl)ethyl]acetamide

Product 1

HCID 22747878HCID 22747878, compound

Procedure

A solution of 11 g of N-[(1RS)-1-hydroxymethyl-2-(2-pyrazinyl)ethyl]acetamide in 30 cm3 of 5N hydrochloric acid is heated at a temperature in the region of 115° C. for 18 hours. The reaction mixture is concentrated under reduced pressure (1 kPa) at a temperature in the region of 40° C. 7.9 g of (2RS)-2-amino-3-(2-pyrazinyl)-1-propanol dihydrochloride are obtained in the form of a black paste [mass spectrum: DCI m/z=154 MH+]

Workup

  1. concentrationThe reaction mixture is concentrated under reduced pressure (1 kPa) at a temperature in the region of 40° C

Sources & evidence

ORD record
ord-fbde21d8daa24def8dd159032cb1aae0
Source dataset
uspto-grants-2004_03
Patent number
US06699895B2

Reaction notes

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