Hydrochloric Acid → HCID 178440261, compound

HRID 477726Notes

Reaction equation

HRID 477726 reaction equation
[C:1]([N:6]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[NH:7][C:8]([NH2:10])=[S:9])(=O)[CH2:2][CH2:3][CH3:4].Cl>C(=O)([O-])[O-].[Na+].[Na+]>[SH:9][C:8]1[N:10]=[C:1]([CH2:2][CH2:3][CH3:4])[N:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19872278HCID 19872278, compound

Product 1

HCID 178440261HCID 178440261, compoundYield 89.3%

Reagents, catalysts & solvents 1

HCID 10340Sodium CarbonateSolvent

Procedure

A suspension of the product of stage (a) (40 g) in aqueous 10% sodium carbonate solution (200 ml) was heated under reflux for 2 hours. The clear yellow solution obtained was cooled and acidified with concentrated hydrochloric acid to afford an off-white precipitate. This was filtered off and recrystallised from ethanol to give the desired product (33 g), as white needles, mp 142°-143° C.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hours
  3. customThe clear yellow solution obtained
  4. temperaturewas cooled
  5. customto afford an off-white precipitate
  6. filtrationThis was filtered off
  7. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-fc6f0473708040b4a4c074f3df9429fe
Source dataset
uspto-grants-1989_12
Patent number
US04889553

Reaction notes

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