HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → 1-Acetyl-5-amino-3-benzylthio-1,2,4-triazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-(benzylsulfanyl)-4H-1,2,4-triazol-3-amine | HCID 737272 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-Acetyl-5-amino-3-benzylthio-1,2,4-triazole | HCID 14255122 | — |
Reaction Steps
Acetyl chloride (12.57 g) in methylene chloride (30 ml) was added to the product of stage (a) (30 g) in triethylamine (25 ml) and methylene chloride (300 ml) at 0° C., and the mixture was stirred for 30 minutes. Then 1N sodium hydroxide was added, and the solution was extracted with methylene chloride. On drying, and recrystallisation from ethyl acetate, 33 g of the desired product, mp 146° C., were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04889553 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-57814ae2c7a04ef7a48bcf4cf2092c22 |
| Source note | uspto-grants-1989_12 |