Acetyl chloride → HCID 19872293, compound

HRID 477752Notes

Reaction equation

HRID 477752 reaction equation
[CH2:1]([S:8][C:9]1[N:13]=[C:12]([OH:14])[N:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:21](Cl)(=[O:23])[CH3:22]>C1(C)C=CC=CC=1>[C:21]([O:14][C:12]1[N:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:10]=[C:9]([S:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[N:13]=1)(=[O:23])[CH3:22]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 178518539HCID 178518539, compound

Product 1

HCID 19872293HCID 19872293, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of the product of stage (c) (20 g), toluene (150 ml) and acetyl chloride (12.2 ml) was heated under reflux for 5 hours. The volatile materials were removed in vacuo, and the residue was triturated with ether and filtered off. Recrystallisation from ethanol gave 19.8 g of desired product.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 5 hours
  3. customThe volatile materials were removed in vacuo
  4. customthe residue was triturated with ether
  5. filtrationfiltered off
  6. customRecrystallisation from ethanol

Sources & evidence

ORD record
ord-e7422cc80fb543809bd09614b2f11978
Source dataset
uspto-grants-1989_12
Patent number
US04889553

Reaction notes

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