反应详情

a solution of 0.3 g of tert-butyl N-[(4RS)-4-(1,2,4-triazol-1-yl-methyl)-4,5-dihydro-2-thiazolyl]carbamate in 10 cm3 of 4N hydrochloric acid in dioxane is stirred at a temperature in the region of 20° C. for 34 hours. The reaction medium is filtered and then washed with 3 times 5 cm3 of diethyl ether and dried in a desiccator. 0.14 g of (4RS)-4-(1,2,4-triazol-1-ylmethyl)-4,5-dihydro-2-thiazolylamine dihydrochloride is obtained in the form of a white foam [mass spectrum: EI m/z=184 MH+ m/z=183 M+ m/z=114 C4H6N2+M/z=101 C3H5N2S+ base peak m/z=36 HCl DCI m/z=184 MH+].

1. filtrationThe reaction medium is filtered
2. washwashed with 3 times 5 cm3 of diethyl ether
3. customdried in a desiccator