反应详情

To a solution of 1.5 g of sodium metal in 100 ml of ethanol are added 8 g of 3-fluorophenol and 17 g of ethyl 5-fluoro-2-bromomethylbenzoate [U.S. Pat. No. 4,082,850]and the mixture is refluxed with heating for 8 hours. After cooling, 300 ml of water is added and the mixture is extracted with toluene. The extract is washed with water and a saturated saline solution and dried over magnesium sulfate. The solvent is distilled off under reduced pressure to give 20 g of ethyl 5-fluoro-2-[(3-fluorophenyl oxy)methyl]benzoate (oil). Mass spectrum m/z: 292(M+).

1. temperature4,082,850]and the mixture is refluxed
2. temperaturewith heating for 8 hours
3. temperatureAfter cooling
4. extractionthe mixture is extracted with toluene
5. washThe extract is washed with water
6. dry with materiala saturated saline solution and dried over magnesium sulfate
7. distillationThe solvent is distilled off under reduced pressure