HCID 14652594, compound → HCID 14652596, compound

HRID 477822Notes

Reaction equation

HRID 477822 reaction equation
[ClH:1].Cl.[CH2:3]([N:10]([CH2:12][CH2:13][CH:14]1[O:19][CH2:18][CH2:17][N:16](CC2C=CC=CC=2)[CH2:15]1)C)C1C=CC=CC=1>O.C(O)C.[C].[Pd]>[ClH:1].[ClH:1].[CH3:3][NH:10][CH2:12][CH2:13][CH:14]1[O:19][CH2:18][CH2:17][NH:16][CH2:15]1

Participants

5

Reactant 1

HCID 14652594HCID 14652594, compound

Product 1

HCID 14652596HCID 14652596, compound

Reagents, catalysts & solvents 3

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolventHCID 962WaterSolvent

Procedure

The solvent is concentrated under reduced pressure and the residue is treated with 25% hydrochloric acid-ethanol in ethanol to give 2-[2-(N-benzyl-N-methylamino)ethyl]-4-benzylmorpholine dihydrochloride as white crystals, melting at 256°-258° C. with decomposition. The obtained hydrochloride compound (5.25 g) is subjected to catalytic reduction with 1 g of 10% palladium-carbon in 50 ml of water and 200 ml of ethanol. After absorbing the theoretical volume of the hydrogen, the catalyst is filtered off and the filtrate is concentrated under reduced pressure. The residue is treated with ethanol to give 2-(2-methylaminoethyl)morpholine dihydrochloride, melting at 179°-181° C. with decomposition.

Workup

  1. customAfter absorbing the theoretical volume of the hydrogen
  2. filtrationthe catalyst is filtered off
  3. concentrationthe filtrate is concentrated under reduced pressure
  4. additionThe residue is treated with ethanol

Sources & evidence

ORD record
ord-a0d3b80a9f094a6d941ebd9fd9a38d1c
Source dataset
uspto-grants-1989_12
Patent number
US04889857

Reaction notes

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