HCID 14652594, compound → HCID 14652596, compound

Participants

Reaction Steps

The solvent is concentrated under reduced pressure and the residue is treated with 25% hydrochloric acid-ethanol in ethanol to give 2-[2-(N-benzyl-N-methylamino)ethyl]-4-benzylmorpholine dihydrochloride as white crystals, melting at 256°-258° C. with decomposition. The obtained hydrochloride compound (5.25 g) is subjected to catalytic reduction with 1 g of 10% palladium-carbon in 50 ml of water and 200 ml of ethanol. After absorbing the theoretical volume of the hydrogen, the catalyst is filtered off and the filtrate is concentrated under reduced pressure. The residue is treated with ethanol to give 2-(2-methylaminoethyl)morpholine dihydrochloride, melting at 179°-181° C. with decomposition.

Provenance & Evidence