1-(2,4-Difluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid → 1-(2,4-Difluorophenyl)-6,8-difluoro-1,4-dihydro-7-[2-(2-methylaminoethyl)morpholino]-4-oxoquinoline-3-carboxylic acid

HRID 477853Notes

Reaction equation

HRID 477853 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:18]2[C:13](=[CH:14][C:15]([F:21])=[C:16](F)[C:17]=2[F:19])[C:12](=[O:22])[C:11]([C:23]([OH:25])=[O:24])=[CH:10]1.[CH3:26][NH:27][CH2:28][CH2:29][CH:30]1[O:35][CH2:34][CH2:33][NH:32][CH2:31]1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:18]2[C:13](=[CH:14][C:15]([F:21])=[C:16]([N:32]3[CH2:33][CH2:34][O:35][CH:30]([CH2:29][CH2:28][NH:27][CH3:26])[CH2:31]3)[C:17]=2[F:19])[C:12](=[O:22])[C:11]([C:23]([OH:25])=[O:24])=[CH:10]1

Participants

3

Reactant 2

HCID 144760111-(2,4-Difluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acidHCID 14652595HCID 14652595, compound

Product 1

HCID 198349561-(2,4-Difluorophenyl)-6,8-difluoro-1,4-dihydro-7-[2-(2-methylaminoethyl)morpholino]-4-oxoquinoline-3-carboxylic acid

Procedure

By the use of 1-(2,4-difluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and 2-(2 -methylaminoethyl)morpholine, the reaction is similarly carried but as Example 26 to give 1-(2,4-difluorophenyl)-6,8-difluoro-1,4-dihydro-7-[2-(2-methylaminoethyl)morpholino]-4-oxoquinoline-3-carboxylic acid.

Sources & evidence

ORD record
ord-800d5f9ed24b4549a7dde4abf7b491a8
Source dataset
uspto-grants-1989_12
Patent number
US04889857

Reaction notes

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