反应详情

To a mixture of 4-chloroaniline (14.51 g) and 4-methoxy-2-nitrobenzenesulfonyl chloride (28.54 g) was added dropwise aqueous sodium hydroxide solution (0.7 N, 162 ml) over a period of 30 minutes at 70° C. After addition, the mixture was stirred for 30 minutes at the same temperature. The colled mixture was diluted with aqueous IN-hydrochloric acid. The separated oil was extracted with ethyl acetate. The extract was dried over magnesium sulfate and concentrated under reduced pressure. The yellow solid was triturated with n-hexame and collected by filtration to yield 4-methoxy-2-nitro-N-(4-chlorophenyl) benzenesulfonamide (37,23 g).

1. additionAfter addition
2. extractionThe separated oil was extracted with ethyl acetate
3. dry with materialThe extract was dried over magnesium sulfate
4. concentrationconcentrated under reduced pressure
5. customThe yellow solid was triturated with n-hexame and
6. filtrationcollected by filtration