反应详情

A solution of 0.1 g of 5-(p-tert-butylaminocarbonylphenyl)imidazo[1,5-a]pyridine in 3 ml of toluene is treated with 40 μl of phosphorus oxychloride at 90° for 5 h. The solvent is evaporated and the residue is redissolved in 30 ml of chloroform at 0°. An ice-cold ammonium hydroxide solution is added and the organic phase is separated, dried over sodium sulfate and evaporated. The residue is chromatographed on silica with ethyl acetate to yield the title compound, m.p. 117°-118°.

1. customThe solvent is evaporated
2. dissolutionthe residue is redissolved in 30 ml of chloroform at 0°
3. additionAn ice-cold ammonium hydroxide solution is added
4. customthe organic phase is separated
5. dry with materialdried over sodium sulfate
6. customevaporated
7. customThe residue is chromatographed on silica with ethyl acetate