HCID 54307199, compound → HCID 386443, compound

HRID 478035Notes

Reaction equation

HRID 478035 reaction equation
C([O:3][C:4](=[O:18])[CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH2:6][S:7]([CH3:10])(=[O:9])=[O:8])C>Cl>[CH2:11]([CH:5]([CH2:6][S:7]([CH3:10])(=[O:9])=[O:8])[C:4]([OH:18])=[O:3])[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 1

HCID 54307199HCID 54307199, compound

Product 1

HCID 386443HCID 386443, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

1.74 g of 2-benzyl-3-methylsulphonyl-propionic acid ethyl ester in 35 ml of 4N hydrochloric acid are heated under reflux for 2 hours. The cooled solution is extracted with ethyl acetate, the extracts are dried and concentrated and the residue is purified by medium-pressure chromatography (1 Lobar® column size B, eluant A). 1H-NMR (DMSO-d6): 2.95 ppm(s, 3H); 2.8-3.8 (m, 5H); 7.2 (s, 5H).

Workup

  1. temperatureunder reflux for 2 hours
  2. extractionThe cooled solution is extracted with ethyl acetate
  3. customthe extracts are dried
  4. concentrationconcentrated
  5. customthe residue is purified by medium-pressure chromatography (1 Lobar® column size B, eluant A)

Sources & evidence

ORD record
ord-f1fed78e049d4a5e9fd1ee5b7091228b
Source dataset
uspto-grants-1989_12
Patent number
US04889869

Reaction notes

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