HCID 54136212, compound → HCID 19860254, compound

HRID 478038Notes

Reaction equation

HRID 478038 reaction equation
C([O:3][C:4](=[O:23])[CH:5]([CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH2:6][S:7]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1)(=[O:9])=[O:8])C>Cl.O>[CH2:16]([CH:5]([CH2:6][S:7]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1)(=[O:9])=[O:8])[C:4]([OH:23])=[O:3])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 1

HCID 54136212HCID 54136212, compound

Product 1

HCID 19860254HCID 19860254, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Procedure

233 mg of 2-benzyl-3-(2-pyridyl)sulphonyl-propionic acid ethyl ester are boiled under reflux for 2 hours in 4 ml of 4N HCl. The reaction mixture is diluted with water and extracted with ethyl acetate. The organic phases are washed with water, dried and concentrated by evaporation. The residue is chromatographed by evaporation. The residue is chromatographed on silica gel with eluant H and yields white crystals of the title compound of Rf (I)=0.3.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe organic phases are washed with water
  3. customdried
  4. concentrationconcentrated by evaporation
  5. customThe residue is chromatographed by evaporation
  6. customThe residue is chromatographed on silica gel with eluant H

Sources & evidence

ORD record
ord-014c4395f9f54e28b18d5a8efeb221a5
Source dataset
uspto-grants-1989_12
Patent number
US04889869

Reaction notes

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