Methanol → HCID 178494695, compound

HRID 478059Notes

Reaction equation

HRID 478059 reaction equation
[Na].Cl[CH2:3][C:4]1[N:5]=[C:6]([OH:14])[C:7]2[S:13][CH2:12][CH2:11][CH2:10][C:8]=2[N:9]=1.[CH3:15][OH:16]>>[OH:14][C:6]1[C:7]2[S:13][CH2:12][CH2:11][CH2:10][C:8]=2[N:9]=[C:4]([CH2:3][O:16][CH3:15])[N:5]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 5360545SodiumHCID 178517759HCID 178517759, compound

Product 1

HCID 178494695HCID 178494695, compound

Procedure

Sodium metal (0.46 g, 0.02 gr. atm.) was dissolved in methanol (100 ml) and the product from step A was added. The reaction mixture was refluxed for 4 hours and then most of the solvent was removed in vacuo. The addition of water afforded 1.2 g of title compound which was dried and used in step C without further purification.

Workup

  1. temperatureThe reaction mixture was refluxed for 4 hours
  2. custommost of the solvent was removed in vacuo
  3. additionThe addition of water

Sources & evidence

ORD record
ord-5b61135f6b514ce38c2b90b4957a2f3e
Source dataset
uspto-grants-1989_12
Patent number
US04889856

Reaction notes

Loading…