Hydrochloric Acid → Hydrochloric Acid

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A solution of 3-(4-{1-((tert-butoxycarbonyl-heptyl-amino)-methyl]-cyclopropyl}-phenyl)-2-ethoxy-propionic acid methyl ester (1.29 mmol, 615 mg) in ethyl acetate (20 mL) under a nitrogen atmosphere was cooled to −78° C., and saturated with HCl gas. The solution was allowed to warm to room temperature and the solvent was evaporated, leaving the 2-ethoxy-3-[4-(1-heptylaminomethyl-cyclopropyl)-phenyl]-propionic acid methyl ester as its HCl salt (531 mg, 100%).

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