Hydrochloric Acid → Hydrochloric Acid

HRID 47808Notes

Reaction equation

HRID 47808 reaction equation
[CH3:1][O:2][C:3](=[O:34])[CH:4]([O:31][CH2:32][CH3:33])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2([CH2:15][N:16](C(OC(C)(C)C)=O)[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH2:14][CH2:13]2)=[CH:8][CH:7]=1.[ClH:35]>C(OCC)(=O)C>[CH3:1][O:2][C:3](=[O:34])[CH:4]([O:31][CH2:32][CH3:33])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2([CH2:15][NH:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH2:13][CH2:14]2)=[CH:8][CH:7]=1.[ClH:35]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 698840843-(4-{1-((Tert-butoxycarbonyl-heptyl-amino)-methyl]-cyclopropyl}-phenyl)-2-ethoxy-propionic acid methyl ester

Product 2

HCID 313Hydrochloric AcidYield 100%HCID 698835502-Ethoxy-3-[4-(1-heptylaminomethyl-cyclopropyl)-phenyl]-propionic acid methyl ester

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of 3-(4-{1-((tert-butoxycarbonyl-heptyl-amino)-methyl]-cyclopropyl}-phenyl)-2-ethoxy-propionic acid methyl ester (1.29 mmol, 615 mg) in ethyl acetate (20 mL) under a nitrogen atmosphere was cooled to −78° C., and saturated with HCl gas. The solution was allowed to warm to room temperature and the solvent was evaporated, leaving the 2-ethoxy-3-[4-(1-heptylaminomethyl-cyclopropyl)-phenyl]-propionic acid methyl ester as its HCl salt (531 mg, 100%).

Workup

  1. customthe solvent was evaporated

Sources & evidence

ORD record
ord-e47d787a4d384e0a862e28d84b84e10d
Source dataset
uspto-grants-2004_03
Patent number
US06699904B2

Reaction notes

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