Benzyl Chloride → HCID 14877716, compound

HRID 478097Notes

Reaction equation

HRID 478097 reaction equation
[CH2:1]([O:19][CH2:20][CH:21]([CH2:23][O:24][CH2:25][CH2:26][O:27][CH2:28][CH2:29][O:30][CH2:31][CH2:32][O:33]C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[OH:22])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[CH2:53](Cl)[C:54]1[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=1.[OH-].[Na+]>[Cl-].C([N+](C)(C)C)CCCCCCCCCCCCCCC>[CH2:53]([O:22][CH:21]([CH2:20][O:19][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH2:23][O:24][CH2:25][CH2:26][O:27][CH2:28][CH2:29][O:30][CH2:31][CH2:32][OH:33])[C:54]1[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=1

Participants

5

Reactant 3

HCID 7503Benzyl ChlorideHCID 14798Sodium HydroxideHCID 148777141-O-Octadecyl-3-O-[2-[2-(2-trityloxyethoxy)ethoxy]ethyl]glycerol

Product 1

HCID 14877716HCID 14877716, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 8154Hexadecyltrimethylammonium chlorideCatalyst

Procedure

7.2 g (10 millimole) of 1-O-octadecyl-3-O-[2-[2-(2-trityloxyethoxy)ethoxy]ethyl]glycerol, 2.5 g (20 millimole) of benzyl chloride, 4 g (50 millimole) of 50% sodium hydroxide, 160 mg (0.5 millimole) of cetyltrimethylammonium chloride were treated by following a procedure similar to that described in Working Example 10, to give 5.1 g (88%) of the above-captioned compound.

Sources & evidence

ORD record
ord-2cb5392bf2af4bc3b73b7889fe07ea5f
Source dataset
uspto-grants-1989_12
Patent number
US04889953

Reaction notes

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