HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Chloride → 2-O-Benzyl-1-O-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]-3-O-octadecylglycerol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Chloride | HCID 7503 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-O-Octadecyl-3-O-[2-[2-(2-trityloxyethoxy)ethoxy]ethyl]glycerol | HCID 14877714 | — |
| Catalyst | Hexadecyltrimethylammonium chloride | HCID 8154 | — |
| Product | 2-O-Benzyl-1-O-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]-3-O-octadecylglycerol | HCID 14877716 | 90% |
Reaction Steps
7.2 g (10 millimole) of 1-O-octadecyl-3-O-[2-[2-(2-trityloxyethoxy)ethoxy]ethyl]glycerol, 2.5 g (20 millimole) of benzyl chloride, 4 g (50 millimole) of 50% sodium hydroxide, 160 mg (0.5 millimole) of cetyltrimethylammonium chloride were treated by following a procedure similar to that described in Working Example 10, to give 5.1 g (88%) of the above-captioned compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04889953 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-2cb5392bf2af4bc3b73b7889fe07ea5f |
| Source note | uspto-grants-1989_12 |