HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Cyano-3-cyclohexyl-3-oxo-propionic acid ethyl ester → 3-Cyclohexyl-3-oxopropanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Cyano-3-cyclohexyl-3-oxo-propionic acid ethyl ester | HCID 23544543 | — |
| Solvent | (Methanesulfinyl)methane--water (1/1) | HCID 23503278 | — |
| Product | 3-Cyclohexyl-3-oxopropanenitrile | HCID 11309597 | — |
Reaction Steps
A solution of 2-cyano-3-cyclohexyl-3-oxo-propionic acid ethyl ester in DMSO:water (10:1) was stirred at 120° C. for 2 hours. The reaction mixture was partitioned between ether and 1N HCl, the organic phase was dried with MgSO4 and the solvent removed under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06642227B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-77dd8144fad54d2a9f71c7b13b36520b |
| Source note | uspto-grants-2003_11 |