HCID 18001201, compound → 6306-59-8

HRID 478200Notes

Reaction equation

HRID 478200 reaction equation
[ClH:1].[CH2:2]([N:9]([CH2:11][CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)C)C1C=CC=CC=1>CO.[Pd]>[ClH:1].[CH3:2][NH:9][CH2:11][CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

4

Reactant 1

HCID 18001201HCID 18001201, compound

Product 1

HCID 180012586306-59-8Yield 115.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 1-(3-(N-benzyl-N-methylamino)propyl)piperidine hydrochloride (0.82 g, 2.6 mmol) in methanol (50 mL) was added 5% palladium/carbon (0.16 g), and the mixture was stirred under hydrogen atmosphere at room temperature overnight. After filtrating the reaction mixture through Celite, the filtrate was concentrated to afford the title compound (0.58 g, yield: 99%) as white crystals.

Workup

  1. filtrationAfter filtrating the reaction mixture through Celite
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-de99b76076ba445c9a66437efc6a03b0
Source dataset
uspto-grants-2003_11
Patent number
US06642228B1

Reaction notes

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