HRID47826

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID94416

p-Isopropylphenyl isocyanate

C10H11NO

结构：CCCCCCCN(CCc1ccc(CC(OCc2ccccc2)C(=O)OCC)cc1)C(=O)OC(C)(C)C

HCID69884390

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCN(CCc1ccc(CC(OCc2ccccc2)C(=O)OCC)cc1)C(=O)Nc1ccc(C(C)C)cc1

HCID69884479

未命名化合物

PROCEDURE

实验过程

Synthesized from 2-benzyloxy-3-{4-[2-(tert-butoxycarbonyl-heptyl-amino)-ethyl]-phenyl}-propionic acid ethyl ester using procedures analogous to that used for Example 8 immediately followed by Example 10 and substituting 1-isocyanato-4-isopropyl-benzene in the place of 2,4-dimethoxyphenylisocyanate to give crude 2-benzyloxy-3-(4-{2-[1-heptyl-3-(4-isopropyl-phenyl)-ureido]-ethyl}-phenyl)-propionic acid ethyl ester.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b5646f7611804af9a28a66bae5ac82c7
来源数据集: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06699904B2
来源说明: uspto-grants-2004_03

反应 SMILES

[CH2:1]([O:3][C:4](=[O:38])[CH:5]([O:30][CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][N:15](C(OC(C)(C)C)=O)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:9][CH:8]=1)[CH3:2].[N:39]([C:42]1[CH:47]=[CH:46][C:45]([CH:48]([CH3:50])[CH3:49])=[CH:44][CH:43]=1)=[C:40]=[O:41]>>[CH2:1]([O:3][C:4](=[O:38])[CH:5]([O:30][CH2:31][C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][N:15]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[C:40]([NH:39][C:42]2[CH:47]=[CH:46][C:45]([CH:48]([CH3:50])[CH3:49])=[CH:44][CH:43]=2)=[O:41])=[CH:9][CH:8]=1)[CH3:2]