HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 478301Generated: October 29, 2026
N-bromobutanimide → 9-(3,4-dibromophenyl)-5,9-dihydro-3H-furo [3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione
https://huagongshe.com/reaction/478301
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | methyl 4-(3,4-dibromophenyl)-2-methyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate | HCID 18001000 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 9-(3,4-dibromophenyl)-5,9-dihydro-3H-furo [3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione | HCID 10275046 | 46.4% |
Reaction Steps
The product from Example 71A (0.095 g, 0.21 mmol) in chloroform (5 mL) was treated with N-bromosuccinimide (0.037 g, 0.21 mmol) and heated to 110° C. for 16 hours. The mixture was cooled to ambient temperature and purified by chromatography on silica gel eluting with 5% methanol in dichloromethane to provide the title compound (0.043 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06642222B2 |
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| Source dataset | uspto-grants-2003_11 |
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| ORD ID | ord-f2ff994bb75e4afd8eafa98b5dfaed36 |
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| Source note | uspto-grants-2003_11 |
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