Sodium Sulfate → HCID 18002316, compound

HRID 478336Notes

Reaction equation

HRID 478336 reaction equation
C([O:3][C:4]([C:6]1[C:10]([CH2:11][CH3:12])=[N:9][N:8]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:7]=1)=O)C.S([O-])([O-])(=O)=O.[Na+].[Na+]>CCOCC.C1COCC1>[CH2:11]([C:10]1[C:6]([CH2:4][OH:3])=[N:7][N:8]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:9]=1)[CH3:12]

Participants

5

Reactant 2

HCID 24436Sodium SulfateHCID 18002318HCID 18002318, compound

Product 1

HCID 18002316HCID 18002316, compoundYield 98.2%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolvent2×HCID 8028TetrahydrofuranSolvent

Procedure

11.55 g of ethyl-5-ethyl-2-phenyl-1,2,3-triazole-4-carboxylate dissolved in a mixed solvent of 150 ml of ether and 30 ml of THF was added dropwise at 3-8° C. to LiAIH4 suspended in 100 ml of ether. After stirring overnight at room temperature, a small amount of saturated sodium sulfate solution was added thereto. Insoluble materials were filtered off, and the filtrate was dried over anhydrous sodium sulfate. The solvent was distilled off to obtain 9.40 g of the aimed compound.

Workup

  1. additionwas added dropwise at 3-8° C. to LiAIH4
  2. filtrationInsoluble materials were filtered off
  3. dry with materialthe filtrate was dried over anhydrous sodium sulfate
  4. distillationThe solvent was distilled off

Sources & evidence

ORD record
ord-efa41173d8ff401b9ed91befc5e9018a
Source dataset
uspto-grants-2003_11
Patent number
US06642234B1

Reaction notes

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