Hydrochloric Acid → 4-(2-Methylbenzoyl)benzoic acid

HRID 478342Notes

Reaction equation

HRID 478342 reaction equation
[CH3:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[O:13]CC(C)(C)N=2)=[CH:8][CH:7]=1)=[O:5].Cl.[OH2:24]>>[CH3:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[C:4]([C:6]1[CH:7]=[CH:8][C:9]([C:12]([OH:13])=[O:24])=[CH:10][CH:11]=1)=[O:5]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 180010212-[4-(2-Methylbenzoyl)phenyl]-4,4-dimethyl-2-oxazoline

Product 1

HCID 180011004-(2-Methylbenzoyl)benzoic acid

Procedure

2-[4-(2-Methylbenzoyl)phenyl]-4,4-dimethyl-2-oxazoline (2.86 g) and 4.5M hydrochloric acid (150 ml) are refluxed for 8 hours. The mixture is cooled to room temperature, and thereto is added water. The precipitates are collected by filtration to give 4-(2-methylbenzoyl)benzoic acid (2.23 g) as white powder.

Workup

  1. filtrationThe precipitates are collected by filtration

Sources & evidence

ORD record
ord-25408829f86a436bac144309a3de0962
Source dataset
uspto-grants-2003_11
Patent number
US06642223B2

Reaction notes

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