Hydrochloric Acid → HCID 57043464, compound

HRID 478347Notes

Reaction equation

HRID 478347 reaction equation
O[C:2]1([C:8]2[CH:13]=[CH:12][C:11]([C:14]3[O:15]CC(C)(C)N=3)=[C:10]([CH3:21])[CH:9]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.CC1C[O:26]C(C)=N1.Cl>C(O)(=O)C>[C:2]1([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:15])=[O:26])=[C:10]([CH3:21])[CH:9]=2)[CH2:3][CH2:4][CH2:5][CH2:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 5357172,4-Dimethyl-4,5-dihydro-1,3-oxazoleHCID 18001102HCID 18001102, compound

Product 1

HCID 57043464HCID 57043464, compoundYield 80.8%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

To a solution of 2-[4-(1-hydroxy-1-cyclohexyl)-2-methylphenyl]-4,4-dimethyl-2-oxazoline (4.29 g) in acetic acid (40 ml) is added a 10% dimethyl-2-oxazoline (4.29 g) in acetic acid (40 ml) is added a 10% hydrochloric acid (20 ml), and the mixture is refluxed for two days. The precipitated crystals are collected by filtration, washed with water, and dried to give 4-cyclohexenyl-2-methylbenzoic acid (2.61 g) as white powder.

Workup

  1. temperaturethe mixture is refluxed for two days
  2. filtrationThe precipitated crystals are collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-4df16d336bc9408b8b7b1127abfc6b8b
Source dataset
uspto-grants-2003_11
Patent number
US06642223B2

Reaction notes

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