Iodoethane → 1-Ethyl-1,4-diazepane

HRID 478351Notes

Reaction equation

HRID 478351 reaction equation
[NH:1]1[CH2:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH2:8](I)[CH3:9]>C(O)C>[CH2:8]([N:1]1[CH2:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1)[CH3:9]

Participants

4

Reactant 2

HCID 6340IodoethaneHCID 68163Hexahydro-1,4-diazepine

Product 1

HCID 75775381-Ethyl-1,4-diazepane

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Homopiperazine (100 g) is dissolved in ethanol (500 ml), and thereto is added dropwise gradually ethyl iodide (19.8 ml). The mixture is stirred at room temperature overnight, and the insoluble materials are removed by filtration. The filtrate is evaporated to remove the solvent. Purification is performed by distillation to give 1-ethylhomopiperazine (50 g) as colorless oil.

Workup

  1. customthe insoluble materials are removed by filtration
  2. customThe filtrate is evaporated
  3. customto remove the solvent
  4. customPurification
  5. distillationis performed by distillation

Sources & evidence

ORD record
ord-803173f9fa0b40ecba84aa61ca8d6b95
Source dataset
uspto-grants-2003_11
Patent number
US06642223B2

Reaction notes

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