Pyrrolidine → HCID 131724143, compound

HRID 478394Notes

Reaction equation

HRID 478394 reaction equation
[F:1][C:2]([F:35])([F:34])[C:3]1[CH:4]=[C:5]([C:13]([N:15]2[CH2:20][CH2:19][C@H:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C@H:17]([C:27]3[CH:32]=[CH:31][CH:30]=[C:29](Cl)[CH:28]=3)[CH2:16]2)=[O:14])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[NH:36]1[CH2:40][CH2:39][CH2:38][CH2:37]1.C1(C2C=CC=CC=2)C=CC=CC=1P(C1CCCCC1)C1CCCCC1>>[F:1][C:2]([F:35])([F:34])[C:3]1[CH:4]=[C:5]([C:13]([N:15]2[CH2:20][CH2:19][C@H:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C@H:17]([C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([N:36]4[CH2:40][CH2:39][CH2:38][CH2:37]4)[CH:28]=3)[CH2:16]2)=[O:14])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1

Participants

4

Reactant 3

HCID 31268PyrrolidineHCID 27342162-(Dicyclohexylphosphino)biphenylHCID 131724121HCID 131724121, compound

Product 1

HCID 131724143HCID 131724143, compound

Procedure

The title compound, MS: m/e=547.4 (M+), was prepared in accordance with the general method of example 10 from rac-cis-(3,5-bis-trifluoromethyl-phenyl)-[3-(3-chloro-phenyl)-4-phenyl-piperidin-1-yl]-methanone, pyrrolidine and biphenyl-2-yl-dicyclohexyl-phosphane as ligand.

Sources & evidence

ORD record
ord-bfb789bff5e749ca9f75b478b8dbc9d9
Source dataset
uspto-grants-2003_11
Patent number
US06642226B2

Reaction notes

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