1-Methylpiperazine → HCID 131724152, compound

HRID 478402Notes

Reaction equation

HRID 478402 reaction equation
C([N:8]1[CH2:13][CH2:12][C:11](=O)[CH:10]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[CH3:21])[CH2:9]1)C1C=CC=CC=1.[CH3:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1.[F:29][C:30]([F:45])([F:44])[C:31]1[CH:32]=[C:33]([CH:37]=[C:38]([C:40]([F:43])([F:42])[F:41])[CH:39]=1)[C:34](Cl)=[O:35]>>[F:29][C:30]([F:45])([F:44])[C:31]1[CH:32]=[C:33]([C:34]([N:8]2[CH2:13][CH2:12][C@H:11]([N:26]3[CH2:27][CH2:28][N:23]([CH3:22])[CH2:24][CH2:25]3)[C@H:10]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[CH3:21])[CH2:9]2)=[O:35])[CH:37]=[C:38]([C:40]([F:43])([F:42])[F:41])[CH:39]=1

Participants

4

Reactant 3

HCID 531671-MethylpiperazineHCID 1018563,5-Bis(trifluoromethyl)benzoyl chlorideHCID 18001144HCID 18001144, compound

Product 1

HCID 131724152HCID 131724152, compound

Procedure

The title compound, MS: m/e=514.3 (M+H+), was prepared in accordance with the general method of example 26 from 1-benzyl-3-o-tolyl-piperidin-4-one, N-methyl-piperazine and 3,5-bistrifluoromethyl-benzoyl chloride.

Sources & evidence

ORD record
ord-bf79e79d46e2496f953e00408cbf134d
Source dataset
uspto-grants-2003_11
Patent number
US06642226B2

Reaction notes

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