Piperazine → Rac-cis-1-(1-benzyl-3-phenyl-piperidin-4-yl)-piperazine

To a mixture of 1-benzyl-3-phenyl-piperidin-4-one (10.0 g, 37.7 mmol) and piperazine (13.0 g, 151 mmol) was added tetraisopropyl-orthotitanate (42.8 mL, 151 mmol) at room temperature. After stirring at room temperature overnight the reaction mixture was diluted with ethanol (300 mL) and sodium cyanoborohydride (10.5 g, 151 mmol) was added. The reaction mixture was stirred at room temperature for 24 h and was diluted with water (10 mL). The inorganic precipitate was filtered off and washed with ethanol. The solvent was evaporated and the residue was taken up in ethylenglycol (130 mL) and sodium hydroxide (13.6 g, 37.7 mmol) was added. The reaction mixture was stirred at 130° C. for 15 min. After cooling water (200 mL) was added and the mixture was extracted twice with 200 mL diethylether. Organic phases were pooled, dried with magnesium sulfate and evaporated. Flash chromatography on silica gel with methylene chloride/triethyl amine 99:1 gave rac-cis-1-(1-benzyl-3-phenyl-piperidin-4-yl)-piperazine (4.63 g, 36%), as a yellow oil, MS: m/e=336.3 (M+H+).

1. additionwas added tetraisopropyl-orthotitanate (42.8 mL, 151 mmol) at room temperature
2. additionwas added
3. stirringThe reaction mixture was stirred at room temperature for 24 h
4. filtrationThe inorganic precipitate was filtered off
5. washwashed with ethanol
6. customThe solvent was evaporated
7. stirringThe reaction mixture was stirred at 130° C. for 15 min
8. additionwas added
9. extractionthe mixture was extracted twice with 200 mL diethylether
10. dry with materialdried with magnesium sulfate
11. customevaporated

ORD record

ord-2ebc2a16d1484edda9f32f8451d89ff1

Source dataset

uspto-grants-2003_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06642226B2