HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Bis(trifluoromethyl)benzoyl chloride → Rac-cis-(3,5-bis-trifluoromethyl-phenyl)-[4-(4-cyclopropyl-piperazin-1-yl)-3-phenyl-piperidin-1-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Bis(trifluoromethyl)benzoyl chloride | HCID 101856 | — |
| Reactant | 1-Cyclopropylpiperazine | HCID 4742004 | — |
| Reactant | 1-Benzyl-3-phenylpiperidin-4-one | HCID 11817956 | — |
| Product | Rac-cis-(3,5-bis-trifluoromethyl-phenyl)-[4-(4-cyclopropyl-piperazin-1-yl)-3-phenyl-piperidin-1-yl]-methanone | HCID 131724166 | — |
Reaction Steps
The title compound, MS: m/e=526.1 (M+H+), was prepared in accordance with the general method of example 26 from 1-benzyl-3-phenyl-piperidin-4-one, N-cyclopropyl-piperazine and 3,5-bistrifluoromethyl-benzoyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06642226B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-4a37a21387ff4021a01f16d89812d6f7 |
| Source note | uspto-grants-2003_11 |