HRID478415

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID101856

3,5-Bis(trifluoromethyl)benzoyl chloride

C9H3ClF6O

HCID4742004

1-Cyclopropylpiperazine

C7H14N2

HCID11817956

1-BENZYL-3-PHENYLPIPERIDIN-4-ONE

C18H19NO

PRODUCTS

生成物

结构：O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CC[C@H](N2CCN(C3CC3)CC2)[C@H](c2ccccc2)C1

HCID131724166

未命名化合物

PROCEDURE

实验过程

The title compound, MS: m/e=526.1 (M+H+), was prepared in accordance with the general method of example 26 from 1-benzyl-3-phenyl-piperidin-4-one, N-cyclopropyl-piperazine and 3,5-bistrifluoromethyl-benzoyl chloride.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4a37a21387ff4021a01f16d89812d6f7
来源数据集: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06642226B2
来源说明: uspto-grants-2003_11

反应 SMILES

C([N:8]1[CH2:13][CH2:12][C:11](=O)[CH:10]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:9]1)C1C=CC=CC=1.[CH:21]1([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH2:23][CH2:22]1.[F:30][C:31]([F:46])([F:45])[C:32]1[CH:33]=[C:34]([CH:38]=[C:39]([C:41]([F:44])([F:43])[F:42])[CH:40]=1)[C:35](Cl)=[O:36]>>[F:30][C:31]([F:46])([F:45])[C:32]1[CH:33]=[C:34]([C:35]([N:8]2[CH2:13][CH2:12][C@H:11]([N:27]3[CH2:28][CH2:29][N:24]([CH:21]4[CH2:23][CH2:22]4)[CH2:25][CH2:26]3)[C@H:10]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:9]2)=[O:36])[CH:38]=[C:39]([C:41]([F:44])([F:43])[F:42])[CH:40]=1