Pyrrolidine → HCID 131724175, compound

HRID 478424Notes

Reaction equation

HRID 478424 reaction equation
C([N:8]1[CH2:13][CH2:12][C:11](=O)[CH:10]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[CH2:9]1)C1C=CC=CC=1.[NH:22]1[CH2:26][CH2:25][CH2:24][CH2:23]1.[F:27][C:28]([F:43])([F:42])[C:29]1[CH:30]=[C:31]([CH:35]=[C:36]([C:38]([F:41])([F:40])[F:39])[CH:37]=1)[C:32](Cl)=[O:33]>>[F:27][C:28]([F:43])([F:42])[C:29]1[CH:30]=[C:31]([C:32]([N:8]2[CH2:13][CH2:12][C@H:11]([N:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)[C@H:10]([C:15]3[CH:16]=[CH:17][C:18]([F:21])=[CH:19][CH:20]=3)[CH2:9]2)=[O:33])[CH:35]=[C:36]([C:38]([F:41])([F:40])[F:39])[CH:37]=1

Participants

4

Reactant 3

HCID 31268PyrrolidineHCID 1018563,5-Bis(trifluoromethyl)benzoyl chlorideHCID 18001158HCID 18001158, compound

Product 1

HCID 131724175HCID 131724175, compound

Procedure

The title compound, MS: m/e=489.3 (M+H+), was prepared in accordance with the general method of example 26 from 1-benzyl-3-(4-fluoro-phenyl)-piperidin-4-one, pyrrolidine and 3,5-bistrifluoromethyl-benzoyl chloride.

Sources & evidence

ORD record
ord-85141ebafacf4b7493a575e0f7e2fde3
Source dataset
uspto-grants-2003_11
Patent number
US06642226B2

Reaction notes

Loading…