Morpholine → Rac-cis-(3,5-bis-trifluoromethyl-phenyl)-[3-(3,4-dichloro-phenyl)-4-morpholin-4-yl-piperidin-1-yl]-methanone

HRID 478431Notes

Reaction equation

HRID 478431 reaction equation
C([N:8]1[CH2:13][CH2:12][C:11](=O)[CH:10]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=2)[CH2:9]1)C1C=CC=CC=1.[NH:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1.[F:29][C:30]([F:45])([F:44])[C:31]1[CH:32]=[C:33]([CH:37]=[C:38]([C:40]([F:43])([F:42])[F:41])[CH:39]=1)[C:34](Cl)=[O:35]>>[F:29][C:30]([F:45])([F:44])[C:31]1[CH:32]=[C:33]([C:34]([N:8]2[CH2:13][CH2:12][C@H:11]([N:23]3[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)[C@H:10]([C:15]3[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=3)[CH2:9]2)=[O:35])[CH:37]=[C:38]([C:40]([F:43])([F:42])[F:41])[CH:39]=1

Participants

4

Reactant 3

HCID 8083MorpholineHCID 1018563,5-Bis(trifluoromethyl)benzoyl chlorideHCID 180011661-Benzyl-3-(3,4-dichlorophenyl)-4-piperidinone

Product 1

HCID 131724183Rac-cis-(3,5-bis-trifluoromethyl-phenyl)-[3-(3,4-dichloro-phenyl)-4-morpholin-4-yl-piperidin-1-yl]-methanone

Procedure

The title compound, MS: m/e=555.1 (M+H+), was prepared in accordance with the general method of example 26 from 1-benzyl-3-(3,4-dichloro-phenyl)-piperidin-4-one, morpholine and 3,5-bistrifluoromethyl-benzoyl chloride.

Sources & evidence

ORD record
ord-b9951836962443de850a220c15612715
Source dataset
uspto-grants-2003_11
Patent number
US06642226B2

Reaction notes

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