Bromomethylcyclopropane → HCID 131724184, compound

HRID 478432Notes

Reaction equation

[F:1][C:2]([F:35])([F:34])[C:3]1[CH:4]=[C:5]([C:13]([N:15]2[CH2:20][CH2:19][C@H:18]([N:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)[C@H:17]([C:27]3[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=3)[CH2:16]2)=[O:14])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.Br[CH2:37][CH:38]1[CH2:40][CH2:39]1>>[F:11][C:9]([F:10])([F:12])[C:7]1[CH:6]=[C:5]([C:13]([N:15]2[CH2:20][CH2:19][C@H:18]([N:21]3[CH2:22][CH2:23][N:24]([CH2:37][CH:38]4[CH2:40][CH2:39]4)[CH2:25][CH2:26]3)[C@H:17]([C:27]3[CH:28]=[CH:29][C:30]([F:33])=[CH:31][CH:32]=3)[CH2:16]2)=[O:14])[CH:4]=[C:3]([C:2]([F:1])([F:34])[F:35])[CH:8]=1

Participants

Reactant 2

HCID 81503Bromomethylcyclopropane

HCID 131724181HCID 131724181, compound

Product 1

HCID 131724184HCID 131724184, compound

Procedure

The title compound, MS: m/e=558.3 (M+H+), was prepared in accordance with the general method of example 35 from rac-cis-(3,5-bis-trifluoromethyl-phenyl)-[3-(4-fluoro-phenyl)-4-piperazin-1-yl-piperidin-1-yl]-methanone and bromomethyl cyclopropane.

Sources & evidence

ORD record: ord-e15a7b561a21420793891cbb4d026242
Source dataset: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06642226B2

Reaction notes

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