Cyclopropanecarbonyl chloride → HCID 10166721, compound

HRID 478438Notes

Reaction equation

HRID 478438 reaction equation
[F:1][C:2]([F:41])([F:40])[C:3]1[CH:4]=[C:5]([CH:33]=[C:34]([C:36]([F:39])([F:38])[F:37])[CH:35]=1)[C:6]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:19][CH2:18][N:17]([C:20](=[O:25])[C:21](F)(F)F)[CH2:16][CH2:15]2)[CH:10]([C:26]2[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][CH:27]=2)[CH2:9]1)=[O:7].[CH:42]1(C(Cl)=O)C[CH2:43]1>C(Cl)(Cl)Cl>[F:39][C:36]([F:37])([F:38])[C:34]1[CH:33]=[C:5]([C:6]([N:8]2[CH2:13][CH2:12][CH:11]([N:14]3[CH2:19][CH2:18][N:17]([C:20]([CH:21]4[CH2:43][CH2:42]4)=[O:25])[CH2:16][CH2:15]3)[CH:10]([C:26]3[CH:27]=[CH:28][C:29]([CH3:32])=[CH:30][CH:31]=3)[CH2:9]2)=[O:7])[CH:4]=[C:3]([C:2]([F:1])([F:40])[F:41])[CH:35]=1

Participants

4

Reactant 2

HCID 77637Cyclopropanecarbonyl chlorideHCID 18001152HCID 18001152, compound

Product 1

HCID 10166721HCID 10166721, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound, MS: m/e=568.3 (M+H+), [α]58920=−6.48 (c=0.4012, chloroform), was prepared in accordance with the general method of example 102 (part1) and example 38 from (−)-(1-{4-[1-(3,5-bis-trifluoromethyl-benzoyl)-3-p-tolyl-piperidin-4-yl]-piperazin-1-yl}-2,2,2-trifluoro-ethanone and cyclopropyl carbonyl chloride.

Sources & evidence

ORD record
ord-e8507d54defc42629eb74635b3367c7a
Source dataset
uspto-grants-2003_11
Patent number
US06642226B2

Reaction notes

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