Methyl iodide → HCID 10207856, compound

HRID 478444Notes

Reaction equation

HRID 478444 reaction equation
[F:1][C:2]([F:41])([F:40])[C:3]1[CH:4]=[C:5]([CH:33]=[C:34]([C:36]([F:39])([F:38])[F:37])[CH:35]=1)[C:6]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:19][CH2:18][N:17]([C:20](=O)C(F)(F)F)[CH2:16][CH2:15]2)[CH:10]([C:26]2[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][CH:27]=2)[CH2:9]1)=[O:7].CI>C(Cl)(Cl)Cl>[F:40][C:2]([F:1])([F:41])[C:3]1[CH:4]=[C:5]([C:6]([N:8]2[CH2:13][CH2:12][CH:11]([N:14]3[CH2:15][CH2:16][N:17]([CH3:20])[CH2:18][CH2:19]3)[CH:10]([C:26]3[CH:27]=[CH:28][C:29]([CH3:32])=[CH:30][CH:31]=3)[CH2:9]2)=[O:7])[CH:33]=[C:34]([C:36]([F:37])([F:38])[F:39])[CH:35]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 18001152HCID 18001152, compound

Product 1

HCID 10207856HCID 10207856, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound, MS: m/e=514.4 (M+H+), [α]58920=−25.92, [α]54620=−32.60, [α]43620=−71.06, [α]36520=−152.15 (c=0.1196, chloroform), was prepared in accordance with the general method of example 102 from (−)-(1-{4-[1-(3,5-bis-trifluoromethyl-benzoyl)-3-p-tolyl-piperidin-4-yl]-piperazin-1-yl}-2,2,2-trifluoro-ethanone and methyl iodide.

Sources & evidence

ORD record
ord-8f248d073de2434b815cd887a2bf5ae7
Source dataset
uspto-grants-2003_11
Patent number
US06642226B2

Reaction notes

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