(1-Ethoxycyclopropoxy)trimethylsilane → HCID 10142976, compound

HRID 478448Notes

Reaction equation

HRID 478448 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][N:11]([C@H:14]2[CH2:19][CH2:18][N:17]([C:20](=[O:35])[C:21]3[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[C:23]([C:31]([F:34])([F:33])[F:32])[CH:22]=3)[CH2:16][C@H:15]2[C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[CH2:42](OC1(O[Si](C)(C)C)CC1)[CH3:43]>C(Cl)(Cl)Cl>[F:32][C:31]([F:33])([F:34])[C:23]1[CH:22]=[C:21]([C:20]([N:17]2[CH2:18][CH2:19][CH:14]([N:11]3[CH2:12][CH2:13][N:8]([CH:6]4[CH2:43][CH2:42]4)[CH2:9][CH2:10]3)[CH:15]([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[CH2:16]2)=[O:35])[CH:26]=[C:25]([C:27]([F:30])([F:28])[F:29])[CH:24]=1

Participants

4

Reactant 2

HCID 2734686(1-Ethoxycyclopropoxy)trimethylsilaneHCID 86586144HCID 86586144, compound

Product 1

HCID 10142976HCID 10142976, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound, MS: m/e=526.2 (M+H+), [α]58920=−6.17, [α]43620=−23.81, [α]36520=−74.09 (c=0.1134, chloroform), was prepared in accordance with the general method of example 114 (step1) and example 110 (step 2) from (3S,4R) or (3R,4S)-4-[1-(3,5-bis-trifluoromethyl-benzoyl)-3-phenyl-piperidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester and [(1-ethoxycyclopropyl)-oxy]trimethylsilane.

Sources & evidence

ORD record
ord-2305f1adbc0840a9afe1e6296ce31bed
Source dataset
uspto-grants-2003_11
Patent number
US06642226B2

Reaction notes

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