Formaldehyde → HCID 18001173, compound

HRID 478451Notes

Reaction equation

HRID 478451 reaction equation
[F:1][C:2]([F:41])([F:40])[C:3]1[CH:4]=[C:5]([CH:33]=[C:34]([C:36]([F:39])([F:38])[F:37])[CH:35]=1)[C:6]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:19][CH2:18][N:17]([C:20](=O)C(F)(F)F)[CH2:16][CH2:15]2)[CH:10]([C:26]2[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=2)[CH2:9]1)=[O:7].C=O>C(Cl)(Cl)Cl>[F:39][C:36]([F:37])([F:38])[C:34]1[CH:33]=[C:5]([C:6]([N:8]2[CH2:13][CH2:12][CH:11]([N:14]3[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]3)[CH:10]([C:26]3[CH:27]=[CH:28][C:29]([Cl:32])=[CH:30][CH:31]=3)[CH2:9]2)=[O:7])[CH:4]=[C:3]([C:2]([F:40])([F:1])[F:41])[CH:35]=1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 10211148HCID 10211148, compound

Product 1

HCID 18001173HCID 18001173, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound, MS: m/e=534.3 (M+H+), [α]58920=−53.04, [α]54620=−65.78, [α]43620=−135.72, [α]36520=−277.94 (c=0.3846, chloroform), was prepared in accordance with the general methods of example 102 (part1) and example 125 from (−)-(1-{4-[1-(3,5-bis-trifluoromethyl-benzoyl)-3-(4-chloro-phenyl)-piperidin-4-yl]-piperazin-1-yl}-2,2,2-trifluoro-ethanone and formaldehyde.

Sources & evidence

ORD record
ord-d66902f049d1425f84b58b4f00afabd0
Source dataset
uspto-grants-2003_11
Patent number
US06642226B2

Reaction notes

Loading…