(1-Ethoxycyclopropoxy)trimethylsilane → HCID 18001176, compound

HRID 478452Notes

Reaction equation

HRID 478452 reaction equation
[F:1][C:2]([F:41])([F:40])[C:3]1[CH:4]=[C:5]([CH:33]=[C:34]([C:36]([F:39])([F:38])[F:37])[CH:35]=1)[C:6]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:19][CH2:18][N:17]([C:20](=O)[C:21](F)(F)F)[CH2:16][CH2:15]2)[CH:10]([C:26]2[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=2)[CH2:9]1)=[O:7].[CH2:42](OC1(O[Si](C)(C)C)CC1)C>C(Cl)(Cl)Cl>[F:1][C:2]([F:41])([F:40])[C:3]1[CH:4]=[C:5]([C:6]([N:8]2[CH2:13][CH2:12][CH:11]([N:14]3[CH2:15][CH2:16][N:17]([CH:20]4[CH2:42][CH2:21]4)[CH2:18][CH2:19]3)[CH:10]([C:26]3[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=3)[CH2:9]2)=[O:7])[CH:33]=[C:34]([C:36]([F:39])([F:37])[F:38])[CH:35]=1

Participants

4

Reactant 2

HCID 2734686(1-Ethoxycyclopropoxy)trimethylsilaneHCID 10211148HCID 10211148, compound

Product 1

HCID 18001176HCID 18001176, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound, MS: m/e=560.2 (M+H+), [α]58920=−24.38, [α]54620=−30.39, [α]43620=−64.51 (c=0.6154, chloroform), was prepared in accordance with the general methods of example 102 (step1) and example 110 (step2) from (−)-(1-{4-[1-(3,5-bis-trifluoromethyl-benzoyl)-3-(4-chloro-phenyl)-piperidin-4-yl]-piperazin-1-yl}-2,2,2-trifluoro-ethanone and [(1-ethoxycyclopropyl)-oxy]trimethylsilane.

Sources & evidence

ORD record
ord-ea8263fa14b04a34a311a12f703d1e29
Source dataset
uspto-grants-2003_11
Patent number
US06642226B2

Reaction notes

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