(1-Ethoxycyclopropoxy)trimethylsilane → HCID 18001176, compound

Participants

Reaction Steps

The title compound, MS: m/e=560.2 (M+H+), [α]58920=−24.38, [α]54620=−30.39, [α]43620=−64.51 (c=0.6154, chloroform), was prepared in accordance with the general methods of example 102 (step1) and example 110 (step2) from (−)-(1-{4-[1-(3,5-bis-trifluoromethyl-benzoyl)-3-(4-chloro-phenyl)-piperidin-4-yl]-piperazin-1-yl}-2,2,2-trifluoro-ethanone and [(1-ethoxycyclopropyl)-oxy]trimethylsilane.

Provenance & Evidence