HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 1-[(4-Chlorophenyl)methyl]piperidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | 1-Chloro-4-(chloromethyl)benzene | HCID 7723 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 4-Piperidone | HCID 33721 | — |
| Solvent | Ethyl ketone | HCID 7288 | — |
| Product | 1-[(4-Chlorophenyl)methyl]piperidin-4-one | HCID 10561067 | — |
Reaction Steps
Dissolve 4-piperidone (17 mmol) in 3-pentanone (25 mL) and heat to reflux. Add cesium carbonate (19 mmol) and a catalytic amount of potassium iodide, followed by 4-chlorobenzyl chloride (20 mmol). Stir and reflux for 4 hours. Filter the hot suspension, wash the residue with hot acetone (4×20 mL), combine the filtrate and washings, and evaporate the solvent in vacuo to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06642231B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-fce42884432e4682b6dacf9b981b421f |
| Source note | uspto-grants-2003_11 |