反应详情

Dissolve 4-piperidone (17 mmol) in 3-pentanone (25 mL) and heat to reflux. Add cesium carbonate (19 mmol) and a catalytic amount of potassium iodide, followed by 4-chlorobenzyl chloride (20 mmol). Stir and reflux for 4 hours. Filter the hot suspension, wash the residue with hot acetone (4×20 mL), combine the filtrate and washings, and evaporate the solvent in vacuo to give the title compound.

1. temperatureheat to reflux
2. temperaturereflux for 4 hours
3. filtrationFilter the hot suspension
4. washwash the residue with hot acetone (4×20 mL)
5. customevaporate the solvent in vacuo