4-Piperidone → 1-[(Pyridin-4-yl)methyl]piperidin-4-one

HRID 478510Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][C:4](=[O:7])[CH2:3][CH2:2]1.Cl.[N:9]1[CH:14]=[CH:13][C:12]([CH2:15]Cl)=[CH:11][CH:10]=1>>[N:9]1[CH:14]=[CH:13][C:12]([CH2:15][N:1]2[CH2:6][CH2:5][C:4](=[O:7])[CH2:3][CH2:2]2)=[CH:11][CH:10]=1

Participants

Reactant 2

HCID 337214-Piperidone

HCID 745704-(Chloromethyl)pyridinium chloride

Product 1

HCID 109978151-[(Pyridin-4-yl)methyl]piperidin-4-one

Procedure

1-(4-Pyridinylmethyl)-4-piperidone is prepared from 4-piperidone and 4-picolyl chloride hydrochloride essentially as described above in Example 38, Scheme C, step a.

Sources & evidence

ORD record: ord-896646f76ee24d57ab7794a6ca96c0ee
Source dataset: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06642231B2

Reaction notes

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