2,6-dichloro-9-cyclopentyl-9H-purine → HCID 17922306, compound

HRID 478564Notes

Reaction equation

HRID 478564 reaction equation
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[C:4](Cl)[N:3]=1.NC1CCN(CC2CCOC2)CC1>C(N(CC)CC)C>[CH:11]1([N:8]2[CH:7]=[N:6][C:5]3[C:9]2=[N:10][CH:2]=[N:3][CH:4]=3)[CH2:12][CH2:13][CH2:14][CH2:15]1

Participants

4

Reactant 2

HCID 108011162,6-dichloro-9-cyclopentyl-9H-purineHCID 18001793HCID 18001793, compound

Product 1

HCID 17922306HCID 17922306, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

2-Chloro-6-[4-(1-3-tetrahydrofuranyl)methyl)piperidinylamino]-9-cyclopentylpurine is prepared from 2,6-dichloro-9-cyclopentylpurine, 4amino-1-(3-tetrahydrofuranylmethyl)piperidine, and triethylamine essentially as described above in Example 1, Scheme A, step b.

Sources & evidence

ORD record
ord-f744ee19aaa645068789e40d25269e60
Source dataset
uspto-grants-2003_11
Patent number
US06642231B2

Reaction notes

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