2,6-dichloro-9-cyclopentyl-9H-purine → HCID 178521607, compound

HRID 478580Notes

Reaction equation

HRID 478580 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[C:4](Cl)[N:3]=1.[NH2:17][C@@H:18]1[CH2:23][CH2:22][C@H:21]([OH:24])[CH2:20][CH2:19]1>C(N(CC)CC)C>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[C:4]([NH:17][C@H:18]2[CH2:23][CH2:22][C@@H:21]([OH:24])[CH2:20][CH2:19]2)[N:3]=1

Participants

4

Reactant 2

HCID 108011162,6-dichloro-9-cyclopentyl-9H-purineHCID 178511714HCID 178511714, compound

Product 1

HCID 178521607HCID 178521607, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Cis-2-chloro-6-[(4-hydroxy)cyclohexylamino]-9-cyclopentylpurine is prepared from 2,6-dichloro-9-cyclopentylpurine, cis-4-(amino)cyclohexanol, and triethylamine essentially as described above in Example 1, Scheme A, step b.

Sources & evidence

ORD record
ord-d2de3ebbc4a44475a3259dc67f34f934
Source dataset
uspto-grants-2003_11
Patent number
US06642231B2

Reaction notes

Loading…