HRID478599

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID222

Ammonia gas

H3N

反应SMILES：COc1ccc(Cn2cc3c(N)c(C(=O)Oc4c(F)c(F)c(F)c(F)c4F)c(Cl)nc3n2)cc1

HCID59108869

未命名化合物

PRODUCTS

产物

反应SMILES：COc1ccc(Cn2cc3c(N)c(C(N)=O)c(Cl)nc3n2)cc1

HCID12114402

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

A solution of 4-amino-6-chloro-2-(4-methoxyphenyl)methyl-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid pentafluorophenyl ester (374 mg) in anhydrous THF was saturated with NH3 gas and stirred overnight. Removal of the solvent gave the desired product as a white solid (contain some pentafluorophenol). LC: 2.60 (Gradient 1); MH+: 332.

WORKUP

后处理

customRemoval of the solvent