HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 478618Generated: October 26, 2026
Hydrochloric Acid → 4-(Piperazin-1-yl)benzoic acid hydrochloride
https://huagongshe.com/reaction/478618
Participants
| Role | Name | HCID | Charge |
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| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 4-(piperazin-1-yl)benzoate | HCID 15429161 | — |
| Product | 4-(Piperazin-1-yl)benzoic acid hydrochloride | HCID 16876122 | — |
Reaction Steps
4-piperazin-1-yl-benzoic acid methyl ester (17 mmol) is dissolved in 6N HCl (25 ml) and heated under reflux for 3 hours. The mixture is cooled in an ice bath to 0-4° C. and the solid material formed is filtered off, washed with acetone and dried (vacuum). A white powder with mp. >240° C. is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06642239B2 |
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| Source dataset | uspto-grants-2003_11 |
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| ORD ID | ord-3527e5e768e14be3a0d0fb426d462b76 |
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| Source note | uspto-grants-2003_11 |
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