Hydrochloric Acid → 4-(Piperazin-1-yl)benzoic acid hydrochloride

HRID 478618Notes

Reaction equation

HRID 478618 reaction equation
C[O:2][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1.[ClH:17]>>[ClH:17].[N:10]1([C:7]2[CH:6]=[CH:5][C:4]([C:3]([OH:16])=[O:2])=[CH:9][CH:8]=2)[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 15429161Methyl 4-(piperazin-1-yl)benzoate

Product 1

HCID 168761224-(Piperazin-1-yl)benzoic acid hydrochloride

Conditions

Temperature
2 °C

Procedure

4-piperazin-1-yl-benzoic acid methyl ester (17 mmol) is dissolved in 6N HCl (25 ml) and heated under reflux for 3 hours. The mixture is cooled in an ice bath to 0-4° C. and the solid material formed is filtered off, washed with acetone and dried (vacuum). A white powder with mp. >240° C. is obtained.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 3 hours
  3. customthe solid material formed
  4. filtrationis filtered off
  5. washwashed with acetone
  6. customdried (vacuum)
  7. customA white powder with mp. >240° C. is obtained

Sources & evidence

ORD record
ord-3527e5e768e14be3a0d0fb426d462b76
Source dataset
uspto-grants-2003_11
Patent number
US06642239B2

Reaction notes

Loading…