反应详情

温度

2 °C

4-piperazin-1-yl-benzoic acid methyl ester (17 mmol) is dissolved in 6N HCl (25 ml) and heated under reflux for 3 hours. The mixture is cooled in an ice bath to 0-4° C. and the solid material formed is filtered off, washed with acetone and dried (vacuum). A white powder with mp. >240° C. is obtained.

1. temperatureheated
2. temperatureunder reflux for 3 hours
3. customthe solid material formed
4. filtrationis filtered off
5. washwashed with acetone
6. customdried (vacuum)
7. customA white powder with mp. >240° C. is obtained