Hydrochloric Acid → 4-(4-Benzyl-piperazin-1-yl)-benzoic acid hydrochloride

Participants

Reaction Conditions

Reaction Steps

4-(4-Benzyl-piperazin-1-yl)-benzoic acid methyl ester (0.84 mmol) is dissolved in 4N HCl (2 ml) and heated under reflux for 8 hours. The mixture is cooled in an ice bath to 0-4° C. and the solid material formed is filtered off, washed with cold acetone and dried (vacuum). A grey powder with mp. >270° C., Rf=0.18 (CH2Cl2/MeOH=95:5) is obtained.

Provenance & Evidence