Hydrochloric Acid → 4-(4-Benzyl-piperazin-1-yl)-benzoic acid hydrochloride

HRID 478632Notes

Reaction equation

HRID 478632 reaction equation
C[O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:12][CH2:11]2)=[CH:6][CH:5]=1.[ClH:24]>>[ClH:24].[CH2:16]([N:13]1[CH2:12][CH2:11][N:10]([C:7]2[CH:6]=[CH:5][C:4]([C:3]([OH:23])=[O:2])=[CH:9][CH:8]=2)[CH2:15][CH2:14]1)[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 534068034-(4-Benzyl-piperazin-1-YL)-benzoic acid methyl ester

Product 1

HCID 451589404-(4-Benzyl-piperazin-1-yl)-benzoic acid hydrochloride

Conditions

Temperature
2 °C

Procedure

4-(4-Benzyl-piperazin-1-yl)-benzoic acid methyl ester (0.84 mmol) is dissolved in 4N HCl (2 ml) and heated under reflux for 8 hours. The mixture is cooled in an ice bath to 0-4° C. and the solid material formed is filtered off, washed with cold acetone and dried (vacuum). A grey powder with mp. >270° C., Rf=0.18 (CH2Cl2/MeOH=95:5) is obtained.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 8 hours
  3. customthe solid material formed
  4. filtrationis filtered off
  5. washwashed with cold acetone
  6. customdried (vacuum)
  7. customA grey powder with mp. >270° C., Rf=0.18 (CH2Cl2/MeOH=95:5) is obtained

Sources & evidence

ORD record
ord-535226801e8d4c52a6dc9ac94a76743b
Source dataset
uspto-grants-2003_11
Patent number
US06642239B2

Reaction notes

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